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KMID : 0352519860230010465
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Korea Univercity Medical Journal
1986 Volume.23 No. 1 p.465 ~ p.470
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The Experimental Study on Pathological Changes of Rabbit Small Intestine Following Single Irradiation of Super-Voltage Gamma Ray
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崔日淳/Choi, Il-Soon
薛惠榮/徐源赫/Seol, Hae-Young/Suh, Won-Hyuck
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Abstract
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When super-voltage cobalt 60 gamma ray treat many kinds of intra-abdominal tumors the-small intestine is exposed to unwanted radiation effect and excessive amount of radiation dose is harmful for the small intestine. Author attempted the experimental study to search for maximum tolerable radiation dose of small intsetine.
The pathological changes of small intestine of the rabbits following 1, 500 rads, 2,50a, rads and 3,500 rads single exposure of Cobalt 60 gamma ray have obtained with 80 experimental rabbits.
The doses of 1,500 rads, 2,500 rads and 3,500 rads single exposures were equivalent of biologic effects of 4, 500 rads in 4.5 weeks, 7, 000 rads in 7 weeks and 9, 000 rads in 9 weeks each other.
Following 1,500 rads single exposure rabbits were terminated in 2, 4, 8 weeks intervals,. 2,500 rads single exposure rabbits were terminated in 1, 2, 4 weeks intervals and 3,500 rads single exposure rabbits were terminated at two weeks period. And the small intestines were fixed to Formalin Solution immediately after dissection.
The pathological changes were as follows:
1. Following 1,500 rads single exposure, 10%(3/30) of rabbits were dead by radiation, and the small intestinal mucosa showed the r_ecrosis of 100% in 2 weeks subgroup and thcinflammation of 73% and regeneration of 63% in 2,4 and 8 weeks subgroups.
2. Following 2,500 rads single exposure, 57%(17/30) of rabbits were dead and the small intestinal mucosa showed the necrosis of 87%, inflammation of 89% and regeneration of 53% in 1 week, 2 weeks and 4 weeks subgroups.
3. Following 3,500 rats single exposure, 93%(14/15) of rabbits were dead and the small.
intestine showed necrosis of 100% and inflammation of 47% in 2 weeks subgroup.
4. 4 rabbits showed the metaplastic changes on small intestine in 1,500 rads and 2,500 rads single exposure groups.
In conclusion, over 1, 500 rads single exposure by using high energy radiation caused severe radiation effects and metaplastic changes on small intestines of rabbits.
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